Scientific Publications

MyoKardia Scientific Publications & Presentations

Most Recent

Mavacamten

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy

Annals of Internal Medicine / Heitner, et al

April 2019

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Proceedings of the National Academy of Sciences of the United States of America / Anderson, et al

August 2018

PIONEER-HCM Cohort B Results: Reduction in Left Ventricular Outflow Tract Gradient with Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients

American College of Cardiology 2018 / Jacoby, et al

March 2018

In vivo Cardiac Effects of Mavacamten (MYK- 461): Evidence for Negative Inotropy and Improved Compliance

AHA Scientific Sessions 2017 Presentation / del Rio, et al

November 2017

PIONEER-HCM: A Phase 2 study of Mavacamten (formerly MYK-461) in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients

HFSA 2017 Presentation / Heitner et al

September 2017

HCM

Machine Learning Detection of Obstructive Hypertrophic Cardiomyopathy Using a Wearable Biosensor

AHA Scientific Sessions 2017 / Green et al

November 2017

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

Proceedings of the National Academy of Sciences of the United States of America / J.R. Homburger et al

May 2016

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

Proceedings of the National Academy of Sciences / Sommese, R. et al

July 2013

The Management of Hypertrophic Cardiomyopathy

New England Journal of Medicine / Spirito, P. et al

March 1997

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